Breakthrough in understanding insulin form of laminitis

July 5, 2011

Researchers have made a major breakthrough in understanding how the insulin form of laminitis occurs.

Drs Melody de Laat and Chris Pollitt, of the Australian Equine Laminitis Research Unit at the University of Queensland, have discovered that receptors designed to receive insulin-like growth factor 1 (IGF-1) may be binding to insulin instead, in horses with high levels of insulin.

This groundbreaking discovery in research funded by the US-based Animal Health Foundation may enable scientists to develop strategies to try to block IGF-1 receptors from receiving insulin and prevent the disease from occurring.

The receptor has also been shown to be responsible for the metastatis of malignant tumors in humans, and drugs are currently being developed to block the receptor.

These drugs may be of use in trying to treat horses that are prone to laminitis from developing high levels of insulin.

Insulin is important in regulating the blood glucose within animals, but horses that have Equine Metabolic Syndrome and Cushing's disease often have very high levels of insulin.

Pollitt and his team, funded by the foundation since 1995, previously showed that high insulin is one of the major pathways that causes laminitis, but, to this point, they had not understood how.

The equine foot is very dependent on glucose for metabolism, but it is not dependent on insulin to deliver that glucose.

Horses have a large number of IGF-1 receptors in their feet, but no insulin receptors.

Pollitt's team now theorizes that these IGF-1 receptors are being stimulated by insulin that mimics insulin-like growth factor 1 and is binding to these receptors.

When this happens, the laminar epitheleal cells start to proliferate. Normally these cells in the middle of the foot don't multiply. The cells are made at the coronary band and migrate all the way down to the sole without multiplying.

This type of proliferation causes the laminae to stretch and lengthen and the weight of the horse to ruin the bond between the external hoof wall and the bone. The bone changes position, and laminitis occurs.

"We're starting to understand the pathway of how insulin really causes laminitis," said Dr Don Walsh, president of the foundation.