People with mild traumatic brain injuries appear more likely to have cognitive problems one year later, compared to those who were not injured, study findings suggest.
People with poor cognitive outcomes were also more likely to have other symptoms such as anxiety and lower satisfaction with life, researchers reported in Neurology, the medical journal of the American Academy of Neurology.
“Our results suggest that clinically meaningful poor cognitive outcomes, which we defined as cognitive impairment, cognitive decline or both, one year after a concussion may be more common than previously thought,” said study author Dr Raquel Gardner, associate professor of neurology with the University of California San Francisco.
“They also highlight the need to better understand the mechanisms underlying poor cognitive outcome, even after relatively mild brain injuries, to improve therapy for recovery.”
The study looked at 656 people admitted to trauma center emergency rooms with concussions and 156 healthy people without head injuries. Their average age was 40.
Participants were given up to three neurological evaluations after their injury, at two weeks, six months and one year. Each of those evaluations provided five scores from three tests of recall, language skills and other cognitive domains.
Poor cognitive outcome was defined as satisfying the criteria for cognitive impairment, cognitive decline or both. Cognitive impairment was defined as lower-than-expected performance on at least two cognitive tests such as one memory test and one processing speed test. Cognitive decline was defined as clinically meaningful decline on at least two cognitive tests.
Researchers found that 86 out of 656 people with mild brain injuries, or 14%, had poor cognitive outcomes one year later. Of those, 10% had cognitive impairment only, 2% had cognitive decline only and 2% had both. That compares to eight out of 156 people without concussions, or 5%, who had poor cognitive outcomes one year later. Of those healthy people, 3% had cognitive impairment, none had cognitive decline only, and 1% had both.
Researchers also found that people who had depression before their injury, had no health insurance, or had a high school education or less, were more likely to have a poor cognitive outcome than those who were not depressed before the injury, or had insurance or had more than a high school education.
The study team also found that people who had good cognitive outcomes were more likely to have higher life satisfaction one year after their concussion. The life satisfaction test given to participants produces scores from five to 35, with lower scores indicating lower life satisfaction. Those with good cognitive outcomes scored an average of 26 on the test, compared to people with poor cognitive outcomes, who scored an average of 21.
The study does not prove that people with concussions will have worse cognitive outcomes one year later, but it shows an association.
“Previous studies of people with moderate to severe brain injuries show that early, intensive rehabilitation can improve people’s cognitive outcomes over time,” Gardner said.
“More research is needed to find out the role of cognitive rehabilitation on people with more mild brain injuries who are also at risk for poor cognitive outcomes, and how to predict who falls into this risk category.”
A limitation of the study is that people were enrolled at the time of their concussion and their cognitive health before injury was not known.
The study was supported by the National Institutes of Health, National Institute of Neurological Disorders and Stroke and the Department of Defense.