Daily aerobic exercise can significantly reduce the risk of prolonged recovery from concussion among adolescent athletes, fresh research shows.
“The study clearly demonstrates that strict physical rest until symptoms spontaneously resolve is no longer an acceptable way to treat sport-related concussion in adolescents,” said John Leddy, clinical professor of orthopaedics in the Jacobs School of Medicine and Biomedical Science, part of the University at Buffalo in New York.
Leddy and his fellow researchers found that adolescents can speed their recovery after a sport-related concussion and reduce their risk of a protracted recovery if they engage in aerobic exercise within 10 days of getting injured.
Their findings, in a randomized controlled trial conducted by researchers at the university’s Concussion Management Clinic, reproduces and expands on the team’s 2019 study published in the journal JAMA Pediatrics.
The new study, published in The Lancet Child & Adolescent Health, shows for the first time that sub-symptom threshold aerobic exercise — meaning exercise that doesn’t exacerbate symptoms — when initiated within 10 days, reduced a participant’s risk of persistent post-concussion symptoms by 48%.
“Our findings show that to accelerate recovery and reduce the risk of delayed recovery, physicians should not only permit, but they should consider prescribing sub-symptom threshold physical activity early after sport-related concussion,” said Leddy, who is director of the Concussion Management Clinic.
Adolescents are the most vulnerable age group for concussions, and they take the longest time to recover.
The new findings are the result of a large body of work by Leddy and his colleague, Barry Willer, PhD, professor of psychiatry in the university’s medical school, research director in the Concussion Management Clinic and senior author on the paper. Leddy and Willer have spent years investigating how concussions impact young athletes.
Their research, which is internationally known, has played a key role in the evolution of guidelines that no longer state that athletes recovering from concussions should be prescribed complete rest.
They began this line of research in 2000, with an interest in developing a safe and systematic assessment of exercise tolerance, since this was a known problem after concussion.
“We based our approach on how patients with heart disease are prescribed exercise, by identifying a safe threshold below which the patient can exercise,” Leddy said. “We developed our Buffalo Concussion Treadmill Test by adapting a cardiac treadmill test to stress the brain instead of the heart. Since we know that regular aerobic exercise is good for brain health, the goal was to use sub-symptom threshold exercise to see if it could help the concussed brain recover.
“As the current study shows, this approach is non-pharmacological, safe and effective,” said Leddy, adding that no adverse events were reported.
Study participants were adolescents aged 13 to 18 who had been concussed while playing sport. A total of 118 adolescents were included, with 61 receiving the aerobic exercise treatment and 57 receiving the placebo treatment of stretching exercises that did not elevate their heart rate.
Those who participated in the aerobic exercise group took a median of 14 days to recover from concussion versus 19 days for those in the stretching exercise group.
The current study differed from the team’s 2019 study in the following ways:
Two new sites were added. It was conducted with participants seen at community sports medicine clinics affiliated with the University at Buffalo, as well as two hospital-affiliated clinics: one at Children’s Hospital of Philadelphia (connected with the University of Pennsylvania) and Boston Children’s Hospital (connected to Harvard Medical School), which tend to see patients with more significant injuries.
Whereas the previous study relied on participants self-reporting the amount and intensity of exercise they underwent, in the current trial all participants were provided with heart rate monitors to wear while exercising. This allowed the researchers to confirm that the participants actually followed the doctor’s prescription for aerobic exercise.
The study used a different research design called “intent to treat” and included all participants, even those who dropped out before completing the study, an approach that makes it more difficult to obtain positive findings, but which is more reflective of real-world concussion treatment.
The use of heart rate monitors, in particular, revealed to the researchers a more robust picture of the aerobic exercise sessions the participants were pursuing at home.
Willer said they found that participants were quite diligent in following their prescription and, further, that those who followed the prescription or may even have exceeded the exercise prescription of 20 minutes per day recovered much faster than those that did not follow the prescription.
“This finding is important because delayed recovery comes with substantial cost to adolescents, including academic difficulties, risk for depression and reduced quality of life.”
Leddy and Willer said there are several possible reasons why this approach is effective, related to the physiological and neurological benefits that stem from aerobic exercise, including enhancements to neuroplasticity — that is, neuron repair.
“We are very pleased that the results of this second study provide much stronger evidence that the Buffalo Protocol is not only effective, but it is effective whoever provides the treatment and with all adolescent athletes who experience a concussion,” Willer said. “Importantly, the benefits of prescribed aerobic exercise were experienced by both genders equally.”
The research focused exclusively on adolescents recovering from sport-related concussion. Other investigations, focused on adults who have sustained a concussion in a non-sport setting, have found that such an approach can be effective but it doesn’t work as rapidly or effectively as it does for athletes.
In adults, the aerobic exercise approach can work, Leddy said, but it usually has to be combined with other therapies.
“By contrast, this kind of sub-symptom aerobic exercise approach is often the only treatment that adolescent athletes need.”
The research was funded by the American Medical Society for Sports Medicine.
Co-authors with Leddy and Willer at the University at Buffalo are Mohammad Haider, assistant director of research in the university’s Concussion Management Clinic, and Adam Cunningham with the university’s Orthopaedics and Sports Medicine team.
Early targeted heart rate aerobic exercise versus placebo stretching for sport-related concussion in adolescents: a randomised controlled trial
Prof John J Leddy, Prof Christina L Master, Rebekah Mannix, Douglas J Wiebe, Matthew F Grady, William P Meehan, et al.
The Lancet Child & Adolescent Health, September 30, 2021, https://doi.org/10.1016/S2352-4642(21)00267-4