Study links sycamore trees to Atypical Myopathy

Sycamore Maple leaves (Acer pseudoplatanus).
Sycamore Maple leaves (Acer pseudoplatanus). © JoJan

Toxins from the seeds of the sycamore tree (Acer pseudoplatanus) are the likely cause of the often fatal horse disease, Atypical Myopathy, in Europe, a new study concludes.

The research findings were published this month in Equine Veterinary Journal.

The common name for the tree is sycamore in Britain, but it is also known as the sycamore maple in some other countries.

There is further potential for confusion because a completely different tree, Platanus occidentalis, is known as the sycamore, or American Sycamore, in the United States.

The new research follows hot on the heels of a study in the US earlier this year that linked toxins from the box elder tree (Acer negundo) with Seasonal Pasture Myopathy (SPM), the US equivalent of Atypical Myopathy.

The discovery marks an important step for the future prevention of this fatal disease.

Atypical Myopathy is a highly fatal muscle disease in Britain and Northern Europe.

In 10 years, about 20 European countries have reported the disease.

Cases tend to occur repeatedly in the autumn and in the spring following large autumnal outbreaks.

Horses that develop Atypical Myopathy are usually kept in sparse pastures with an accumulation of dead leaves, dead wood and trees in or around the pasture and are often not fed any supplementary hay or feed.

Seasonal Pasture Myopathy is a similar disorder, prevalent in the Midwest US and Eastern Canada, that is now known to be caused by the ingestion of hypoglycin A, contained in seeds from the box elder tree.

The new European research was conducted by an international team led by Dominic Votion, from the University of Liege, and involved 17 horses from Belgium, Germany and The Netherlands, suffering from Atypical Myopathy.

High concentrations of a toxic metabolite of hypoglycin A, were identified in the serum of all of the horses.

The pastures of 12 of the horses were visited by experienced botanists and the Acer pseudoplatanus, the sycamore maple, was found to be present in every case. This was the only tree common to all visited pastures.

Researchers believe hypoglycin A is the likely cause of both Atypical Myopathy in Europe and Seasonal Pasture Myopathy in North America.

The sycamore and the box elder are known to produce seeds containing hypoglycin A and the pastures of the afflicted horses in Europe and the US were surrounded by these trees.

Hypoglycin-A is found in various levels in the seeds of plants in the genus Acer, as well as in various other genera in the family Sapindaceae such as ackee (Blighia sapida).

In ackee, hypoglycin-A levels vary with ripeness of the fruit and, if the fruit is eaten before it is mature, it causes hypoglycaemia to different degrees, including a condition called “Jamaican vomiting sickness” (because of ackee’s use in Jamaican cooking) and occasionally death in humans.

Researchers at the universities of Minnesota and Liege are continuing their work to try to uncover exactly how the equine disease occurs.

Discussing the on-going research there, Dr Adrian Hegeman and Dr Jeff Gillman, of the University of Minnesota, point out: “It is likely that the most important contributing factors to horses becoming poisoned by hypoglycin-A are the availability of seed in the field combined with lack of other feeding options.

“The seeds from two species of maples – box elder and sycamore maples – that we have tested include significant quantities of hypoglycin-A. We know that seeds contain highly variable quantities from seed to seed, even within a single tree.

Box elder tree
Ingestion of seeds from the Box elder tree can cause Seasonal Pasture Myopathy. Box elder seeds before fall. Box elder seeds before fall.

“We do not know yet how hypoglycin-A levels vary seasonally, nor do we know how its abundance varies with different levels of stress to the plant, though this may well explain seasonal variability in the occurrence of the malady. It is possible that conditions that stress the plants may contribute to significant seasonal changes in hypoglycin-A levels. At this point we just don’t know.

“It is common held knowledge that trees under stress usually produce more seed.”

Gillman went on to comment: “Without question, further analysis of the seeds and other tissues from Acer species needs to be performed along with sampling of plant materials over multiple seasons and at various stress levels.

“Additionally, one cannot rule out more complex explanations for the seasonality of disease occurrence such as: animals may begin feeding on seed materials in response to depletion of more palatable choices under drought conditions; or simple explanations such as high wind events driving seeds into fields.

“These sorts of explanations for the occurrence of the disease do not depend on botanical variations in toxicity across seasons, sites or stress levels, yet also require consideration.”

Although limited examples are available, the experience of animals at a pasture site might also confer some degree of behavioral resistance to poisoning due to exposure at sub-lethal levels with prior exposure to seeds in the pasture.

Professor Celia Marr, editor of the Equine Veterinary Journal, said: “This is an important advancement in our understanding of what causes Atypical Myopathy and how it can be prevented.

“In immediate practical terms owners can take prompt measures to avoid exposing their horses to sycamore seeds this autumn.

“Where horses are grazing in the vicinity of sycamore trees, it is imperative that they are provided with sufficient supplementary feed as this will minimise the risk that horses might be tempted to ingest seeds containing this toxin.

“This must be done carefully and leaving wet hay on the ground should be avoided so providing extra carbohydrate feeds may be more practical.”


The European study can be accessed at
Related research from the University of Minnesota can be accessed at


Leave a Reply

Your email address will not be published. Required fields are marked *

Send this to a friend