Connie Hines was never the star of the show, but she remained best known throughout her life for her role in the hit TV show, "Mister Ed".
Hines, 78, died on Friday in Beverly Hills from issues related to heart problems.
Her most famous role was as Carol Post, the husband of Wilbur, who owned the runaway star of the show, the talking palomino horse, Mister Ed.
Hines never appeared to mind that she was overshadowed by a horse in the hit show, which ran on the CBS network in the United States from 1961 to 1966.
However, the fans continued to come throughout the decades as the show proved popular in a series of re-runs.
Hines was born March 24, 1931, in Dedham, Massachusetts.
She moved to New York with a girlfriend after the end of her first marriage.
She did some modelling and commercial work before landing a leading role on the CBS anthology series called Rendezvous, which was filmed in Europe.
After that, it was off to Hollywood. She landed several lesser roles before being cast in Mister Ed.
She had occasional TV roles after that, including in Medical Center, The Mod Squad and Bonanza.
Alan Young played her husband in the 144 episodes of Mister Ed.
The famous theme song was sung by Jay Livingston and the music written by Jack Cookerly and Dave Kahn.
Mister Ed's real name was Bamboo Harvester and his English voice was that of Allan Lane. Mister Ed would only talk to Wilbur and he was a notorious trouble-maker.
Bamboo Harvester was a saddlebred-arabian cross, and was a show and parade horse before starring on TV. He was euthanised in 1968 at the age of 19 because of several health problems, including arthritis. His TV double was a horse named Pumpkin.